Alprazolam, clopidogrel, clozapine, flecainide, haloperidol, phenytoin, tryptophan, vinblastine, imipramine, and warfarin may interact with sarafem.

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See ContraindicationsCaution with concomitant anticoagulantsreduce warfarin dose and monitorMay potentiate CYP2C8 substratesegdabrafenibenzalutamideseizure riskloperamidemontelukastpaclitaxelpioglitazonerosiglitazoneor OATP1B1 substratesegatrasentanatorvastatinbosentanezetimibefluvastatinglyburideSN-38active metabolite of irinotecanrosuvastatinpitavastatinpravastatinrifampinvalsartanolmesartanmay need to reduce dose of these substratesMyopathyrhabdomyolysisand acute renal failure with HMG-CoA reductase inhibitorscolchicineespin elderly or renal dysfunctionSeparate dosing of bile acid-binding resinsegcolestipolby at least 2hrs.

Avoid consuming foods that are high in fat or cholesterol while taking gemfibrozilor the medicine will not be as effective at lowering cholesterol.

The recommended dose of gemfibrozil is 600 mg twice daily30 minutes before breakfast and dinner

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