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Nimodipine is called a calcium channel blocker. The body naturally responds to bleeding by narrowing the blood vessel to slow blood flow. However.when the bleeding is in the brain.stopping blood flow causes more brain damage. Nimodipine is thought to work by relaxing narrowed blood vessels in the brain near the area of bleeding so blood can flow more easily. This effect reduces brain damage.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
If the oral liquid is going to be given through a feeding tube.use the oral syringe that comes with the package to measure the dose. For each dose.refill the nimotop online auctions with saline solution to flush any remaining medicine in the feeding tube into the stomach.
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Mechanism of Action. Nimodipine is a calcium channel blocker. The contractile processes of smooth muscle cells are dependent upon calcium ions.which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments.nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic.allowing it to cross the blood-brain barrier. concentrations of nimodipine as high as 12.5 ng/mL have been detected in the cerebrospinal fluid of nimodipine-treated subarachnoid hemorrhage (SAH) patients. The precise mechanism of action of nimodipine in humans is unknown. Although the clinical studies described below demonstrate a favorable effect of nimodipine on the severity of neurological deficits caused by cerebral vasospasm following SAH.there is no arteriographic evidence that the drug either prevents or relieves the spasm of these arteries. However.whether or not the arteriographic methodology utilized was adequate to detect a clinically meaningful effect.if any.on vasospasm is unknown.
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